Organic Photo-Electrochemical Transistor-Based Biosensor: A Proof-of-Concept Study toward Highly Sensitive DNA Detection.
Jiajun SongPeng LinYi-Fan RuanWei-Wei ZhaoWeiwei WeiJin HuShanming KeXierong ZengJing-Juan XuHong-Yuan ChenWei RenFeng YanPublished in: Advanced healthcare materials (2018)
Organic bioelectronics have shown promising applications for various sensing purposes due to their significant advantages in term of high flexibility, portability, easy fabrication, and biocompatibility. Here, a new type of organic device, organic photo-electrochemical transistor (OPECT), is reported, which is the combination of an organic electrochemical transistor and a photo-electrochemical gate electrode modified with CdS quantum dots (QDs). Thanks to the inherent amplification function of the transistor, the OPECT-based biosensor exhibits much higher sensitivity than that of a traditional biosensor. The sensing mechanism of the OPECT is attributed to the charge transfer between the photosensitive semiconductor CdS QDs and the gate electrode. In an OPECT-based DNA sensor, target DNA is labeled with Au nanoparticles (NPs) and captured on the gate electrode, which can influence the charge transfer on the gate caused by the exciton-plasmon interactions between CdS QDs and Au NPs. Consequently, a highly sensitive and selective DNA sensor with a detection limit of around 1 × 10-15 m is realized. It is expected that OPECTs can be developed as a high-performance platform for numerous biological detections in the future.
Keyphrases
- label free
- quantum dots
- sensitive detection
- gold nanoparticles
- circulating tumor
- cell free
- molecularly imprinted
- single molecule
- loop mediated isothermal amplification
- energy transfer
- nucleic acid
- water soluble
- ionic liquid
- electron transfer
- reduced graphene oxide
- preterm infants
- high throughput
- circulating tumor cells
- current status
- living cells
- single cell
- mass spectrometry
- real time pcr
- liquid chromatography