Coenzyme Q10 in COPD: An Unexplored Opportunity?
Vladlena I ZozinaSerghei CovantsevV G KukesAlexandru CorlateanuPublished in: COPD (2021)
COPD represents a major cause of mortality and morbidity worldwide, is linked to systemic inflammation and tends to coexist with a variety of comorbidities. Inflammation, oxidative stress and protease-antiprotease imbalance represent the pathogenic triad of COPD. Even though oxidative stress and mitochondrial dysfunction is a well-studied phenomenon in COPD and there is a variety of studies that aim to counteract its effect, there is limited data available on the use of coenzyme Q10 in COPD. The aim of the current review is to analyze the current data on the use of coenzyme Q10 in the management of COPD and frequently encountered comorbidities.
Keyphrases
- chronic obstructive pulmonary disease
- oxidative stress
- lung function
- dna damage
- cystic fibrosis
- air pollution
- electronic health record
- ischemia reperfusion injury
- type diabetes
- cardiovascular events
- machine learning
- signaling pathway
- induced apoptosis
- deep learning
- heat shock
- endoplasmic reticulum stress
- heat shock protein
- case control