Multiple Cognitive and Behavioral Factors Link Association Between Brain Structure and Functional Impairment of Daily Instrumental Activities in Older Adults.

Seyul KwakSu Mi ParkYeong-Ju JeonHyunwoong KoDae Jong OhJun-Young Lee

Published in: Journal of the International Neuropsychological Society : JINS (2021)

Our finding suggests that cerebellar structure and orbitofrontal cortex, alongside with medial temporal lobe, play an important role in the maintenance of functional status in older adults with or without dementia. Moreover, the significance of brain structural volume affects real-life functional activities via disruptions in multiple cognitive and behavioral functions.

Keyphrases

physical activity
resting state
functional connectivity
white matter
mild cognitive impairment
multiple sclerosis
middle aged
community dwelling