Improved multimodal prediction of progression from MCI to Alzheimer's disease combining genetics with quantitative brain MRI and cognitive measures.
Emilie T ReasAlexey ShadrinOleksandr FreiEhsan MotazediLinda McEvoyShahram BahramiDennis van der MeerCarolina MakowskiRobert LoughnanXin WangIris BroceSarah J BanksVera FominykhWeiqiu ChengDominic HollandOlav B SmelandTyler SeibertGeir SelbaekJames B BrewerChun C FanOle A AndreassenAnders M Dalenull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
A multimodal hazard score (MHS) combined age, genetics, brain atrophy, and memory. The MHS predicted time to conversion from mild cognitive impairment to dementia. MHS reduced hypothetical Alzheimer's disease (AD) clinical trial sample sizes by 67%. A polygenic hazard score predicted age of onset of AD neuropathology.