Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice.
Jimin KimSeul Ki LeeMinyoung JungSeon-Yeong JeongHaedeun YouJi-Yeon WonSang-Deok HanHye Jin ChoSomi ParkJoonghoon ParkTae Min KimSeul Ki LeePublished in: Journal of nanobiotechnology (2022)
IFN-γ-iMSC-EVs inhibit Th2-induced immune responses, suppress inflammation, and facilitate skin barrier restoration, contributing to AD improvement.
Keyphrases
- immune response
- atopic dermatitis
- mesenchymal stem cells
- dendritic cells
- oxidative stress
- diabetic rats
- high glucose
- umbilical cord
- toll like receptor
- high fat diet induced
- bone marrow
- soft tissue
- drug induced
- endothelial cells
- type diabetes
- metabolic syndrome
- insulin resistance
- cell therapy
- skeletal muscle
- inflammatory response