De Novo Complement-Binding Anti-HLA Antibodies in Heart Transplanted Patients Is Associated with Severe Cardiac Allograft Vasculopathy and Poor Long-Term Survival.
Guillaume BaudryMatteo PozziMatthieu AubryElisabeth Hugon-ValletRaluca MocanLara ChalabreyssePhilippe PortranJean-François ObadiaOlivier ThaunatNicolas GirerdValérie DuboisLaurent SebbagPublished in: Journal of clinical medicine (2022)
According to this large monocentric study in heart transplant patients, donor specific antibodies were associated with worse clinical outcome when binding complement. DSA and their complement-binding ability should thus be screened for to optimize heart transplant patient follow-up.