Handling intercurrent events and missing data in non-inferiority trials using the estimand framework: A tuberculosis case study.

Sunita RehalSuzie CroPatrick Peter John PhillipsKatherine FieldingJames R Carpenter

Published in: Clinical trials (London, England) (2023)

Using carefully constructed estimands and appropriate primary and sensitivity estimators, using all the information available, results in a more principled and statistically rigorous approach to analysis. Doing so provides an accurate interpretation of the estimand.

Keyphrases

mycobacterium tuberculosis
wastewater treatment
electronic health record
high resolution
emergency department
hiv aids
human immunodeficiency virus