Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates.

Ming-Hsiu YangJordan R HuntNiusha SharifiRyan A Altman

Published in: Angewandte Chemie (International ed. in English) (2016)

A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)-C(sp(3) ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes.

Keyphrases

reduced graphene oxide
visible light
small molecule
fluorescence imaging
living cells
single molecule
gold nanoparticles
electron transfer