Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis.

Aurigena Antunes de AraújoAline de Sousa Barbosa Freitas PereiraCaroline Addison Carvalho Xavier de MedeirosGerly Anne de Castro BritoRenata Ferreira de Carvalho LeitãoLorena de Souza AraújoPaulo Marcos Matta GuedesSarah HiyariFlávia Q PirihRaimundo Fernandes de Araújo Júnior

Published in: PloS one (2017)

Metformin, at a concentration of 50 mg/kg, decreases the inflammatory response, oxidative stress and bone loss in ligature-induced periodontitis in rats.

Keyphrases

bone loss
oxidative stress
diabetic rats

inflammatory response
dna damage
ischemia reperfusion injury

induced apoptosis
lipopolysaccharide induced
high glucose

lps induced
heat shock
endothelial cells