FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.

Arvind PonnusamySmeeta SinhaGareth D HydeSamantha J Borland Rebecca F TaylorEmma PondHeather J EyreColette A InksonAndrew GilmoreNick AshtonPhilip A KalraAnn E Canfield

Published in: PloS one (2018)

Together, these results demonstrate that FTI-277 inhibits VSMC mineral deposition by up-regulating PI3K/Akt signaling and preventing apoptosis, suggesting that targeting farnesylation, or Akt specifically, may have therapeutic potential for the prevention of vascular calcification.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
smooth muscle
cell proliferation
cell death
chronic kidney disease
oxidative stress
endoplasmic reticulum stress
single cell
cell therapy
mesenchymal stem cells