The sense of stopping migraine prophylaxis.

Linda Al-Hassany Hannah S Lyons Deirdre M Boucherie Fatemeh Farham Kristin Sophie Lange Karol Marschollek Dilara Onan Umberto Pensato Elisabeth Storch Angelo Torrente Marta Waliszewska-Prosol Uwe Reuternull null

Published in: The journal of headache and pain (2023)

Translational and basic studies are warranted to investigate the long-term effects of a preventive drug after its discontinuation, starting from what is known about the biology of migraine. In addition, observational studies and, eventually, clinical trials focusing on the effect of discontinuation of migraine prophylactic therapies, are essential to substantiate evidence-based recommendations on stopping rules for both oral preventives and CGRP(-receptor) targeted therapies in migraine.

Keyphrases

clinical trial
emergency department
clinical practice
open label
study protocol
drug induced