Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesis.
Jyoti TanwarKriti AhujaAkshay SharmaParas SehgalGyan RanjanFarina SultanAnshu PriyaManigandan VenkatesanVamsi K YenamandraArchana SinghMuniswamy MadeshSridhar SivasubbuRajender K MotianiPublished in: bioRxiv : the preprint server for biology (2023)
homeostasis and to ensure optimal melanogenesis Inhibiting MCU with mitoxantrone, an FDA approved drug, leads to reduction in physiological pigmentation.