Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells.

Natalia Kučić Valentino RačkiRoberta ŠverkoToni VidovićIrena GrahovacJasenka Mršić-Pelčić

Published in: International journal of molecular sciences (2021)

By modulating the phenotypic features by metabolic switching of activated microglia, naltrexone was found to be an effective and powerful tool for immunometabolic reprogramming and could be a promising novel treatment for various neuroinflammatory conditions.

Keyphrases

inflammatory response
induced apoptosis
neuropathic pain
cell cycle arrest
lipopolysaccharide induced
lps induced
signaling pathway
alcohol use disorder
endoplasmic reticulum stress
spinal cord
oxidative stress
cell death
combination therapy