Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia.
Thomas DaixRobin JeannetAna Catalina Hernandez PadillaPhilippe VignonJean FeuillardBruno FrancoisPublished in: Journal of intensive care (2021)
During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population.
Keyphrases
- intensive care unit
- acute respiratory distress syndrome
- mechanical ventilation
- sars cov
- pulmonary hypertension
- extracorporeal membrane oxygenation
- emergency department
- end stage renal disease
- coronavirus disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- acute kidney injury
- respiratory syndrome coronavirus
- patient reported outcomes