Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren's syndrome in Mexican population.

Erika Fabiola López-VillalobosFrancisco Josué Carrillo-BallesterosJosé Francisco Muñoz-ValleClaudia Azucena Palafox-SánchezYeminia ValleGerardo Orozco-BarocioEdith Oregon-Romero

Published in: Journal of clinical laboratory analysis (2018)

Our findings suggest that CD28 GC, CTLA4 CAG, and CGA haplotypes are associated with susceptibility to pSS in patients from western Mexico. It seems that genetic control of CD28 and CTLA4 as well as local immune response in glandular tissue may regulate the impact of the gene expression in pSS. It is necessary to confirm this hypothesis in an integrative study.

Keyphrases

gene expression
immune response
end stage renal disease
newly diagnosed
ejection fraction
nk cells
dna methylation
prognostic factors
genome wide
south africa
rheumatoid arthritis
high resolution
mass spectrometry
inflammatory response
gas chromatography