Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease.

Yuanchao ZhangYu ZhangChengjie MaoZhen JiangGuohua FanErlei WangYifan ChenLena Palaniyappan

Published in: Neurology (2023)

We demonstrated progressive reductions in cortical gyrification that were robustly associated with WM microstructure, striatum dopamine availability and serum NfL level in PD. Our findings may contribute biomarkers for PD progression and potential pathways for early interventions of PD.

Keyphrases

parkinson disease
deep brain stimulation
multiple sclerosis
white matter
high resolution
physical activity
metabolic syndrome
prefrontal cortex
mass spectrometry
human health