Levobupivacaine plasma concentrations following repeat caudal anesthetics.

Geoff P Frawley Luis Ignacio Cortinez Brian Joseph AndersonAndrew BjorkstenSebastian K King

Published in: Paediatric anaesthesia (2022)

dose does not exceed the concentration associated with systemic local anesthetic toxicity. In 2.5% of simulated neonates (weight 3.8 kg, PMA 40 weeks), repeat caudal anesthesia demonstrates broaching of the lower concentration limit associated with toxicity at both 3 and 4 h after initial caudal.

Keyphrases

oxidative stress
body mass index
weight gain
low birth weight
gestational age
preterm infants