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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars.

Masayo AokiAkatsuki KondoNoriko MatsunagaAzusa HondaYuri OkuboKazuaki TakabeRei Ogawa
Published in: Journal of immunology research (2020)
Topical FTY720 induces M2 predominance and impairs angiogenesis. Therefore, its local immunosuppressive mechanisms differ from those of conventional immunosuppressive agents. Topical FTY720 can be a novel therapeutic option for abnormal scars that are difficult to control with corticosteroids. Its lymphocytopenic effects may be limited by careful optimization of the treatment regimen.
Keyphrases
  • multiple sclerosis
  • endothelial cells
  • high glucose
  • platelet rich plasma
  • vascular endothelial growth factor
  • diabetic rats
  • replacement therapy
  • stress induced
  • smoking cessation