Heterozygous GABA A receptor β3 subunit N110D knock-in mice have epileptic spasms.

Shimian QuLaurel G JacksonChengwen ZhouDingDing ShenWangzhen ShenGerald NwosuRachel HoweMackenzie A CatronCarson FlammMarshall BivenJing Qiong Kang Robert L Macdonald

Published in: Epilepsia (2022)

mice can be used to study the pathophysiology of infantile spasms. Reduced cortical inhibition and increased duration of thalamocortical oscillatory firing suggest perturbations in thalamocortical circuits.

Keyphrases

high fat diet induced
early onset
high frequency
wild type