Heterozygous GABA A receptor β3 subunit N110D knock-in mice have epileptic spasms.
Shimian QuLaurel G JacksonChengwen ZhouDingDing ShenWangzhen ShenGerald NwosuRachel HoweMackenzie A CatronCarson FlammMarshall BivenJing Qiong KangRobert L MacdonaldPublished in: Epilepsia (2022)
mice can be used to study the pathophysiology of infantile spasms. Reduced cortical inhibition and increased duration of thalamocortical oscillatory firing suggest perturbations in thalamocortical circuits.