Gene expression profiling of lichenoid dermatitis immune-related adverse event from immune checkpoint inhibitors reveals increased CD14+ and CD16+ monocytes driving an innate immune response.

Jonathan L CurryAlexandre ReubenRobert Szczepaniak-SloaneJing NingDenái R MiltonChi H LeeCourtney HudgensSaira GeorgeCarlos A Torres-CabalaDaniel JohnsonSandesh SubramanyaJennifer A WargoKumaran MudaliarIgnacio I WistubaVictor G PrietoAdi DiabMichael T Tetzlaff

Published in: Journal of cutaneous pathology (2019)

LD-irAE exhibited activation of CD14/TLR innate immune response with increased CD14+ and CD16+ monocytes compared with BLK control. CD14/TLR signaling may drive the development of LD-irAE.

Keyphrases

immune response
gene expression
toll like receptor
dendritic cells
nk cells
inflammatory response
emergency department
peripheral blood
nuclear factor
drug induced