DCLK1 Drives EGFR-TKI-Acquired Resistance in Lung Adenocarcinoma by Remodeling the Epithelial-Mesenchymal Transition Status.

Rui YanXuying HuangHeshu LiuZeru XiaoJian LiuGuangyu AnYang Ge

Published in: Biomedicines (2023)

DCLK1 facilitates acquired resistance to EGFR-TKI in lung adenocarcinoma by inducting EMT and accelerating the migration and invasion abilities of TKI-resistant cells.

Keyphrases

tyrosine kinase
epithelial mesenchymal transition
epidermal growth factor receptor
advanced non small cell lung cancer
induced apoptosis
small cell lung cancer
signaling pathway
transforming growth factor
chronic myeloid leukemia
cell cycle arrest
endoplasmic reticulum stress
cell proliferation