Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons.
Muhammad Saad YousufMarisol Mancilla MorenoJiahe LiLucy HeDanielle RoyerJennifer ZhangBrodie J WoodallPeter M GraceTheodore John PricePublished in: bioRxiv : the preprint server for biology (2023)
. MMF prevents MGO-induced aberrant neurite outgrowth in human DRG neurons.Nrf2 activators, like the FDA-approved DRF, is an option to alleviate neuropathic pain in patients with diabetes.