Ionizing radiation-induced "zombie" carcinoma-associated fibroblasts with suppressed pro-radioresistance on OSCC cells.

Yangfan LiuYang WuMiao YangJin YangRuizhan TongWei ZhaoFanglong WuYuan TianXiaoyu LiJingjing Luo Hongmei Zhou

Published in: Oral diseases (2021)

IR-induced zCAFs could continuously promote radioresistance of OSCC cells though being suppressed, suggesting the potential promoting effect on tumor relapse post-radiotherapy that needed further exploring.

Keyphrases

induced apoptosis
high glucose
cell cycle arrest
diabetic rats
early stage
oxidative stress
radiation therapy
endoplasmic reticulum stress
dna damage response
signaling pathway
squamous cell carcinoma
dna damage
endothelial cells
anti inflammatory
risk assessment
cell proliferation
extracellular matrix