Using Ca2+-channel biosensors to profile amphetamines and cathinones at monoamine transporters: electro-engineering cells to detect potential new psychoactive substances.

Published in: Psychopharmacology (2018)

This system constitutes a novel use of voltage-gated Ca2+ channels as biosensors for the purpose of characterizing ligand activity at monoamine transporters using fluorimetry. This approach in combination with in vivo evaluations of drugs' abuse-related effects is a powerful strategy for anticipating potential stimulant-class NPS.

Keyphrases

induced apoptosis
human health
cell cycle arrest
attention deficit hyperactivity disorder
drinking water
protein kinase
risk assessment
endoplasmic reticulum stress
pi k akt