Spindle assembly checkpoint gene BUB1B is essential in breast cancer cell survival.
Dilara KoyuncuUtsav SharmaErik T GokaMarc E LippmanPublished in: Breast cancer research and treatment (2020)
A functional spindle assembly checkpoint is essential for the survival of BrCa cells. BUB1B is a critical factor in SAC, and therefore breast cancer cell survival. Impairment of BUB1B has damaging effects on cancer cell viability and tumorigenicity, especially on the more aggressive variants of BrCa.