Diabetes is accompanied by changes in the levels of proteins involved in endosomal GLUT4 trafficking in obese human skeletal muscle.

Rachel LivingstoneNia J BryantJames G BoyleJohn R Petrie Gwyn W Gould

Published in: Endocrinology, diabetes & metabolism (2022)

We report significant reductions of proteins involved in the endosomal trafficking of GLUT4 in skeletal muscle in obese people with type 2 diabetes compared with age- and weight-matched controls. These abnormalities of intracellular GLUT4 trafficking may contribute to reduced whole body insulin sensitivity.

Keyphrases

skeletal muscle
weight loss
type diabetes
adipose tissue
insulin resistance
metabolic syndrome
endothelial cells
cardiovascular disease
bariatric surgery
obese patients
glycemic control
body mass index
induced pluripotent stem cells
reactive oxygen species
body weight