Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study.
Ross J MarriottKevin MurrayLeon FlickerGraeme J HankeyAlvin M MatsumotoGirish DwivediLeen AntonioOsvaldo P AlmeidaShalender BhasinAdrian S DobsDavid J HandelsmanRobin HaringTerence W O'NeillClaes OhlssonEric S OrwollDirk VanderschuerenGary A WittertFrederick C W WuBu B YeapPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
Lower total testosterone and higher SHBG are independently associated with incident dementia and AD in older men. Additional research is needed to determine causality.