Population pharmacokinetic modelling of febuxostat in healthy subjects and people with gout.

Bishoy KamelAhmad Y AbuhelwaDavid FosterJanna K DuongGarry G GrahamKenneth M WilliamsKevin D PileRichard Osborne Day

Published in: British journal of clinical pharmacology (2022)

Renal function and body mass index were significant covariates. Further work is warranted to investigate the clinical relevance of these results, notably as renal impairment and obesity are common occurrences in people with gout.

Keyphrases

body mass index
uric acid
weight gain
metabolic syndrome
insulin resistance
weight loss
type diabetes
physical activity
high fat diet induced