Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study.
Alison E FohnerTraci M BartzRussell P TracyHieab H H AdamsJoshua C BisLuc DjousséClaudia L SatizabalOscar L LopezSudha SeshadriKenneth J MukamalLewis H KullerBruce M PsatyW T LongstrethPublished in: Neurology (2021)
Among older adults without a history of stroke, higher serum NfL concentration was associated with covert MRI findings of vascular brain injury, especially the burden of WMH and its worsening. Whether these results offer opportunities for the use of NfL as a noninvasive biomarker of WMH or to control vascular risk factors remains to be determined.