Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors.
Ting-Yu LaiTsai-Chen ChiangChih-Yuan LeeTing-Chun KuoChien-Hui WuYi-Ing ChenChun-Mei HuManjit MaskeyShiue-Cheng TangYung-Ming JengYun-Wen TienEva Y-H P LeeWen-Hwa LeePublished in: British journal of cancer (2024)
CAFs drive the growth and metastasis of aggressive PNETs. The CXCR4-SDF1 axis may be a target for antistromal therapy in the treatment of PNET. This study clarifies mechanisms underlying PNET aggressiveness and may guide future therapeutic interventions targeting the tumor microenvironment.