Application of organoid culture from HPV18-positive small cell carcinoma of the uterine cervix for precision medicine.

Misako KusakabeAyumi TaguchiMichihiro TanikawaDaisuke HoshiSaki TsuchimochiXi QianYusuke ToyoharaAkira KawataRyota Wagatsuma Kohei YamaguchiYoko YamamotoMasako IkemuraKenbun SoneMayuyo Mori-UchinoHiroko MatsunagaTetsushi TsurugaTakeshi NagamatsuIwao KukimotoOsamu Wada-HiraikeMasahito KawazuTetsuo UshikuHaruko TakeyamaKatsutoshi OdaKei KawanaYoshitaka HippoYutaka Osuga

Published in: Cancer medicine (2023)

In this study, we confirmed two strategies for identifying therapeutic targets of HPV-derived SCCC, WES for identifying pathogenic variants and RNA sequencing for identifying HPV integration sites. Organoid culture is an effective tool for unveiling the oncogenic process of rare tumors and can be a breakthrough for the development of precision medicine for patients with HPV-positive SCCC.

Keyphrases

high grade
single cell
copy number
gene expression
preterm birth
dna methylation
genome wide