N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension.

Kang KangJingjing XiangXingshi ZhangYuting XieMengting ZhouLe ZengJunhao ZhuangJiahao KuangYuanyuan LinBozhe HuQianmin XiongQing YinQiang SuXiaoyun LiaoJun WangYanqin NiuCuilian LiuJinglin TianDeming Gou

Published in: Cellular & molecular biology letters (2024)

Our findings unveil a novel METTL3/KLF2 pathway critical for protecting hPAECs against EndMT, highlighting a promising avenue for therapeutic investigation in PH.

Keyphrases

pulmonary hypertension
transcription factor
stem cells
bone marrow
pulmonary artery
endothelial cells
pulmonary arterial hypertension
coronary artery