Sex dimorphism in the associations of gestational diabetes with cord blood adiponectin and retinol-binding protein 4.

Meng-Nan YangHuei-Chen ChiuWen-Juan WangFang FangGuang-Hui ZhangHong ZhuLin ZhangDan-Li ZhangQinwen DuHua HeRong HuangXin LiuFei LiJun ZhangFengxiu OuyangXiaolin HuaZhong-Cheng Luo

Published in: BMJ open diabetes research & care (2021)

GD was associated with lower cord plasma HMW adiponectin and higher RBP-4 concentrations in female newborns only. The study is the first to reveal a sex-dimorphic early life impact of GD on metabolic health biomarkers in the offspring. GD may alter the normal presence (HMW adiponectin) or absence (RBP-4) of sex dimorphism in some insulin sensitivity regulation-relevant adipokines in early life.

Keyphrases

early life
cord blood
metabolic syndrome
binding protein
insulin resistance
healthcare
public health
mental health
high fat diet
type diabetes
low birth weight
preterm infants