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Hematological features and alternate diagnoses in critically ill thrombotic antiphospholipid syndrome patients.

Levi-Dan AzoulayThomas FrapardRomaric LarcherFrédéric PèneLaurent ArgaudJulien MayauxMatthieu JammeRemi CoudroyAlexis MathianAude GibelinElie AzoulayYacine Tandjaoui-LambiotteAuguste DargentFrançois-Michel BeloncleJean-Herlé RaphalenNicolas BréchotNicolas de ProstJérôme DevaquetDamien ContouSamuel GaugainPierre TrouillerSteven GrangéStanislas LedochowskiJérémie LemarieStanislas FaguerVincent DegosCorinne FrerePaul QuentricQuentin MoyonCharles-Edouard LuytAlain CombesZahir AmouraMarc Pineton de Chambrun
Published in: Clinical rheumatology (2024)
Thrombocytopenia is very frequent in severe APS patients and may be related to TMA, HIT, or DIC. Deciphering the mechanisms of thrombocytopenia is decisive in CAPS patients. Key Points • Thrombocytopenia is the hallmark laboratory finding in CAPS. • A complete thrombotic microangiopathy pattern is infrequent in CAPS patients. • Alternate diagnoses of CAPS, especially heparin-induced thrombocytopenia, need to be adequately investigated.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • oxidative stress
  • venous thromboembolism
  • early onset
  • endothelial cells
  • drug induced
  • single molecule