Antibacterial, tyrosinase, and DNA photocleavage studies of some triazolylnucleosides.
Surender Kumarnull SukhvinderVinod KumarGirish Kumar GuptaVikas BeniwalFatma AbdmoulehEmna KetataMehdi El ArbiPublished in: Nucleosides, nucleotides & nucleic acids (2017)
In order to explore the biological potential, some synthesized triazolylnucleosides were evaluated for their antibacterial, tyrosinase and DNA photocleavage activities. Triazolylnucleosides (5-12) were screened against Staphylococcus aureus (ATCC 6538), gram-positive and Escherichia coli (ATCC 10536), gram-negative bacterial strains. Among the series, compound 9 exhibited a significant level of antibacterial activity against both strains at higher concentration in reference to the standard drug, Levofloxacin. Tyrosinase activity and inhibition of these compounds were also studied, and it has been found that compounds 8 and 11 displayed more than 50% inhibitory activity. In addition, six compounds (7-12) were evaluated for their DNA photocleavage activity. The compounds 8 and 12 exhibited excellent DNA photocleavage activity at a concentration of 10 μg and may be used as template for antitumor drugs in the future.
Keyphrases
- gram negative
- escherichia coli
- circulating tumor
- cell free
- single molecule
- staphylococcus aureus
- multidrug resistant
- silver nanoparticles
- emergency department
- biofilm formation
- risk assessment
- cystic fibrosis
- drug induced
- high resolution
- current status
- molecularly imprinted
- case control
- essential oil
- electronic health record
- liquid chromatography