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Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.

Triantafyllos DidangelosEleni KarlaftiEvangelia KotzakioulafiEleni MargaritiParthena GiannoulakiGeorgios BatanisSolomon TesfayeKonstantinos Kantartzis
Published in: Nutrients (2021)
The treatment of patients with DN with 1 mg of oral methylcobalamin for twelve months increased plasma B12 levels and improved all neurophysiological parameters, sudomotor function, pain score, and QoL, but it did not improve CARTS and MNSIE.
Keyphrases
  • double blind
  • placebo controlled
  • clinical trial
  • phase iii
  • phase ii
  • chronic pain
  • study protocol
  • type diabetes
  • pain management
  • neuropathic pain
  • open label
  • spinal cord
  • spinal cord injury
  • combination therapy