Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Allyson FlowerAna C XavierMitchell S CairoPublished in: British journal of haematology (2019)
Mature (non-anaplastic) T-cell and natural killer (NK)-lymphomas rarely occur in children or adolescents. Due to the low incidence and heterogeneity, information regarding the aetiology, physiopathology and genetics of paediatric mature (non-anaplastic) T/NK-cell lymphoma is lacking. In addition, standard treatments have not yet been established. In the absence of randomised clinical trials, anthracycline-containing regimens are usually considered as the first treatment option, but with discouraging outcomes, especially in patients with advanced disease. The implementation of autologous or allogeneic stem cell transplantation as upfront consolidation therapy or for chemotherapy-sensitive relapsed disease have resulted in improved survival for some patient subsets. The recent use of novel targeted molecular and immunotherapeutic agents has also been shown to be promising in small numbers of patients. In this context, we will review the current state of the scientific knowledge on the most common mature (non-anaplastic, non-cutaneous) T/NK-cell lymphomas occurring in children, adolescent and young adults.
Keyphrases
- nk cells
- young adults
- stem cell transplantation
- clinical trial
- high dose
- end stage renal disease
- diffuse large b cell lymphoma
- ejection fraction
- newly diagnosed
- intensive care unit
- open label
- emergency department
- mental health
- acute myeloid leukemia
- risk factors
- study protocol
- squamous cell carcinoma
- acute lymphoblastic leukemia
- cell therapy
- prognostic factors
- radiation therapy
- mesenchymal stem cells
- metabolic syndrome
- chronic kidney disease
- quality improvement
- double blind
- phase ii
- hematopoietic stem cell
- phase iii