Folate receptor-mediated delivery of 1-MDT-loaded mesoporous silica magnetic nanoparticles to target breast cancer cells.
Nastaran HashemzadehMitra DolatkhahAyuob AghanejadMohammad Barzegar-JalaliYadollah OmidiKhosro AdibkiaMorteza MahmoudiPublished in: Nanomedicine (London, England) (2021)
Aims: The efficiency of mesoporous silica magnetic nanoparticles (MSMNP) as a targeted drug-delivery system was investigated. Methods: The superparamagnetic iron oxide nanoparticles (NP) were synthesized, coated with mesoporous silica and conjugated with polyethylene glycol and methotrexate. Next, 1-methyl-D-tryptophan was loaded into the prepared nanosystems (NS). They were characterized using transmission electron microscopy, scanning electron microscopy, dynamic light scattering, vibrating sample magnetometer, x-ray powder diffraction, Fourier transform-infrared spectroscopy and the Brunauer-Emmett-Teller method and their biological impacts on breast cancer cells were evaluated. Results: The prepared NSs displayed suitable properties and showed enhanced internalization by folate-receptor-expressing cells, exerting efficient cytotoxicity, which was further enhanced by the near-infrared radiation irradiation. Conclusion: On the basis of our findings, the engineered NS is a promising multifunctional nanomedicine/theranostic for solid tumors.
Keyphrases
- electron microscopy
- magnetic nanoparticles
- iron oxide nanoparticles
- cancer therapy
- breast cancer cells
- drug delivery
- photodynamic therapy
- induced apoptosis
- dengue virus
- cell cycle arrest
- high dose
- radiation induced
- wound healing
- atomic force microscopy
- computed tomography
- cell death
- oxidative stress
- zika virus
- high resolution
- endoplasmic reticulum stress
- magnetic resonance
- metal organic framework
- low dose
- radiation therapy
- cell proliferation
- high speed
- mass spectrometry