Small regulatory RNAs are mediators of the Streptococcus mutans SloR regulon.
India Y DrummondAlessandra DePaoloMadeline KriegerHeather DriscollKorin EckstromGrace A SpataforaPublished in: bioRxiv : the preprint server for biology (2023)
the principal causative agent of dental caries, uses a 25 kDa manganese-dependent protein, called SloR, to coordinate the regulated uptake of essential metal ions with the transcription of its virulence genes. In the present study, we identified and characterize sRNAs that are both SloR- and manganese-responsive. Taken together, this research can elucidate the details of regulatory networks that engage sRNAs in an important oral pathogen, and that can enable the development of an effective anti-caries therapeutic.
Keyphrases
- biofilm formation
- transcription factor
- candida albicans
- pseudomonas aeruginosa
- staphylococcus aureus
- escherichia coli
- genome wide identification
- cancer therapy
- antimicrobial resistance
- quantum dots
- oxide nanoparticles
- amino acid
- protein protein
- gene expression
- oral health
- dna methylation
- binding protein
- aqueous solution