Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease.

Sajad MoshkelgoshaHedda Luise VerhasseltGiulia MasettiDanila CovelliFilippo BiscariniMareike HorstmannAnke DaserAstrid M WestendorfChristoph JesenekSvenja PhilippSalvador Diaz-CanoJ Paul BangaDaryn MichaelSue PlummerJulian R MarchesiAnja EcksteinMarian E LudgateUtta Berchner-Pfannschmidtnull null

Published in: Microbiome (2021)

These results strongly support a role for the gut microbiota in TSHR-induced disease. Whilst changes to the gut microbiota have a profound effect on quantifiable GD endocrine and immune factors, the impact on GO cellular changes is more nuanced. The findings have translational potential for novel, improved treatments. Video abstract.

Keyphrases

mouse model
high glucose
diabetic rats
drug induced
signaling pathway
endothelial cells
intellectual disability
climate change