Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions.
Núria Solà TapiasAlexandre Denadai-SouzaClaire Rolland-FourcadeMuriel Quaranta-NicaiseCatherine BlanpiedMarlène MarcellinAnissa EdirCorinne RollandCarla CirilloGilles DietrichLaurent AlricGuillaume PortierSylvain KirzinDelphine BonnetEmmanuel MasOdile Burlet-SchiltzCéline DeraisonChrystelle BonnartNathalie VergnolleFrédérick BarreauPublished in: Journal of Crohn's & colitis (2022)
Excessive ER stress in IECs caused an increased release of trypsin activity that, in turn, altered intestinal barrier function, promoting the development of inflammatory process.