Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions.

Núria Solà TapiasAlexandre Denadai-SouzaClaire Rolland-FourcadeMuriel Quaranta-NicaiseCatherine BlanpiedMarlène MarcellinAnissa EdirCorinne RollandCarla CirilloGilles DietrichLaurent AlricGuillaume PortierSylvain KirzinDelphine BonnetEmmanuel MasOdile Burlet-SchiltzCéline DeraisonChrystelle BonnartNathalie VergnolleFrédérick Barreau

Published in: Journal of Crohn's & colitis (2022)

Excessive ER stress in IECs caused an increased release of trypsin activity that, in turn, altered intestinal barrier function, promoting the development of inflammatory process.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
oxidative stress
sensitive detection
signaling pathway
physical activity
body mass index
ulcerative colitis