Integrative Prioritization of Causal Genes for Coronary Artery Disease.
Ke HaoRaili ErmelKatyayani SukhavasiHaoxiang ChengLijiang MaLing LiLetizia AmadoriSimon KoplevOscar FranzénValentina d'EscamardNirupama ChandelKathryn WolhuterNicole S BryceVamsidhar R M VenkataClint T MillerArno RuusaleppHeribert SchunkertJohan L M BjorkegrenJason C KovacicPublished in: Circulation. Genomic and precision medicine (2021)
We identified and prioritized candidate causal CAD genes, also localizing their tissue(s) of causal effect. These results should serve as a resource and facilitate targeted studies to identify the functional impact of top causal CAD genes.
Keyphrases
- coronary artery disease
- genome wide
- bioinformatics analysis
- genome wide identification
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- genome wide analysis
- type diabetes
- cardiovascular disease
- heart failure
- gene expression
- cancer therapy
- acute coronary syndrome
- drug delivery
- left ventricular
- atrial fibrillation