Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity.
Tao ZuoQin LiuFen ZhangYun Kit YeohYating WanHui ZhanGrace C Y LuiZigui ChenAmy Y L LiChun Pan CheungNan ChenWenqi LvRita W Y NgEugene Y K TsoKitty S C FungVeronica ChanLowell LingGavin JoyntDavid S C HuiFrancis K L ChanPaul K S ChanWilliam K K WuPublished in: Microbiome (2021)
Both enteric RNA and DNA virome in COVID-19 patients were different from non-COVID-19 subjects, which persisted after disease resolution of COVID-19. Gut virome may calibrate host immunity and regulate severity to SARS-CoV-2 infection. Our observation that gut viruses inversely correlated with both severity of COVID-19 and host age may partly explain that older subjects are prone to severe and worse COVID-19 outcomes. Altogether, our data highlight the importance of human gut virome in severity and potentially therapeutics of COVID-19. Video Abstract.