Genotype-specific methylation of HPV in cervical intraepithelial neoplasia.
Yaw Wen HsuRui-Lan HuangPo-Hsuan SuYu Chih ChenHui Chen WangChi Chun LiaoHung Cheng LaiPublished in: Journal of gynecologic oncology (2018)
Our study showed that the degree of L1 methylation of HPV16, 18, and 52 but not 58 is associated with the severity of cervical lesions. The association between HPV methylation and host gene methylation suggests different responses of host cellular epigenetic machinery to different HPV genotypes.