Response of head and neck epithelial cells to a DNA damage-differentiation checkpoint involving polyploidization.

Natalia Sanz-GómezAna FreijeLaura CeballosSergio ObesoJ Ramón SanzFe García-ReijaCarmelo Morales-AnguloAlberto Gandarillas

Published in: Head & neck (2018)

Keratinocytes from head and neck epithelia share a cell-autonomous squamous DNA damage-differentiation response that is common to the epidermis and might continuously protect them from cancer.

Keyphrases

dna damage
dna repair
oxidative stress
papillary thyroid
single cell
high grade
cell therapy
squamous cell carcinoma
low grade
stem cells
squamous cell
mesenchymal stem cells
cell proliferation
lymph node metastasis