Factors affecting the sodium-glucose cotransporter 2 inhibitors-related initial decline in glomerular filtration rate and its possible effect on kidney outcome in chronic kidney disease with type 2 diabetes: The Japan Chronic Kidney Disease Database.
Tomohiko KanaokaHiromichi WakuiYuichiro YanoHajime NagasuHiroshi KanegaeMasaomi NangakuYosuke HirakawaNaoki NakagawaJun WadaKazuhiko TsuruyaToshiaki NakanoShoichi MaruyamaTakashi WadaMasaaki KonishiTakanori NagahiroKunihiro YamagataIchiei NaritaMotoko YanagitaYoshio TeradaShinichi ArakiMasanori EmotoHirokazu OkadaYoshitaka IsakaYusuke SuzukiTakashi YokooHiromi KataokaEiichiro KandaNaoki KashiharaKouichi Tamuranull nullPublished in: Diabetes, obesity & metabolism (2024)
The concomitant use of renin-angiotensin system inhibitors and diuretics, higher urine protein levels and pre-treatment GFR changes were associated with a larger initial GFR decline. Of these factors, the use of a diuretic had the largest effect. Furthermore, patients with CKD and T2DM experiencing an excessive initial GFR drop might be at a higher risk of adverse kidney outcomes.