Effect of Metformin on Plasma Exposure of Rifampicin, Isoniazid, and Pyrazinamide in Patients on Treatment for Pulmonary Tuberculosis.

Agibothu Kupparam Hemanth KumarAbhijit KadamRamesh KarunaiananthamManoharan TamizhselvanPadmapriyadarsini ChandrasekaranAnant MohanB JeyadeepaAmmayappan RadhakrishnanUrvashi B SinghShraddha BapatAarti ManePradeep KumarMegha MamulwarPerumal Kannabiran BhavaniHemalatha HaribabuNibedita RathRandeep GuleriaAbdul Mabood KhanJaykumar Menonnull null

Published in: Therapeutic drug monitoring (2023)

Metformin altered rifampicin and isoniazid plasma concentrations in patients receiving antituberculosis treatment for pulmonary tuberculosis with little effect on sputum conversion at the end of treatment. Studies with larger sample sizes are needed to understand host drug-drug interactions.

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
end stage renal disease
chronic kidney disease
ejection fraction
combination therapy
peritoneal dialysis