A hairy tale: SIRT7 safeguards skin stem cells during aging.

Matthew SimonStephan EmmrichAndrei SeluanovVera Gorbunova

Published in: The EMBO journal (2020)

Stem cell regulation during both normal development and aging has become one of the fastest growing topics in biology. Here, new work by Li et al (2020) offers insight into the aging process within epithelial skin stem cells and highlights how SIRT7, a member of the sirtuin family of protein deacylases and mono-ADP ribosylases, protects adult hair follicle stem cells from aging by ensuring their hair cycle progression.

Keyphrases

stem cells
cell therapy
soft tissue
wound healing
ischemia reperfusion injury
bone marrow
binding protein