Alcohol consumption and liver phenotype of individuals with alpha-1 antitrypsin deficiency.

Malin Fromme Carolin Victoria SchneiderNurdan GuldikenSamira AmzouYizhao LuoMónica PonsJoan GenescaMarc MiravitllesKatrine Holtz Thorhauge Mattias Mandorfer Johan WaernKai Markus SchneiderJan SperlSona FrankovaMarc BartelHolger ZimmerMarkus ZornAleksander KragAlice TurnerChristian Trautwein Pavel Strnad

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

Pi*MZ/Pi*ZZ genotype does not seem to markedly aggravate the hepatic toxicity of moderate alcohol consumption. CDT values might be helpful to detect alcohol consumption in those with advanced fibrosis. More data are needed to evaluate the impact of harmful alcohol consumption.

Keyphrases

alcohol consumption
oxidative stress
electronic health record
high intensity
big data
liver fibrosis