In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using 68Ga-NODAGA-c(NGR) Peptide.

Adrienn KisNoémi DénesJudit P SzabóViktória AratóLívia BekeOrsolya MatolayKata Nóra EnyediGábor MéhesGábor MezőPéter BaiIstván KertészGyörgy Trencsényi

Published in: BioMed research international (2021)

The bestatin treatment is suitable for suppressing the neoangiogenic process and APN/CD13 expression of experimental HT1080 and B16-F10 tumors; furthermore, 68Ga-NODAGA-c(NGR) is an applicable radiotracer for the in vivo monitoring of the efficacy of the APN/CD13 inhibition-based anticancer therapies.

Keyphrases

pet ct
signaling pathway
computed tomography
combination therapy
pet imaging